Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6.ALPHA.-formamido penicillin.
نویسندگان
چکیده
منابع مشابه
Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6 alpha-formamido penicillin.
Earlier reports from these laboratories outlined the preparationx) and biological properties2>3) of 6a-formamido penicillins. The catecholic acylureido derivative BRL 36650 (1) was the most potent, especially against Pseudomonas aeruginosa strains. Wenowreport on analogues of 1 which either retain a catechol or dihydroxyphenyl unit or contain various catechol isosteres. The general concept of i...
متن کاملIn vitro activity of BRL 36650, a new penicillin.
Compared with four beta-lactam antibiotics and amikacin, BRL 36650 and BMY-28142 were the most active against 509 Enterobacteriaceae, including cefotaxime-resistant isolates and resistant laboratory mutants. BRL 36650 was more active than aztreonam, ceftazidime, and BMY-28142 against Acinetobacter spp., Pseudomonas aeruginosa, and other Pseudomonas spp.; all strains were inhibited by 2 microgra...
متن کاملdetection of volatile compounds of medicinal plants with some nano-sorbents using modified or new methodologies and investigation of antioxidant activity of their methanolic extracts
in this work, a novel and fast method for direct analysis of volatile compounds (davc) of medicinal plants has been developed by holding a filament from different parts of a plant in the gc injection port. the extraction and analysis of volatile components of a small amount of plant were carried out in one-step without any sample preparation. after optimization of temperature, extraction time a...
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN THE CEFPIROME SERIES III. 7a-METHOXY AND 7a-FORMAMIDO ANALOGUES OF CEFPIROME
7«-Methoxy and 7a-formamido derivatives of cefpirome (HR 810) have been synthesized and tested in comparison with cefpirome and some analogues 1 against aerobic and anaerobic bacteria. Cefpirome and analogues 1 have good activity against Gram-positive and only limited activity against Gram-negative anaerobic bacteria. 7a-Methoxy derivatives 2 show only a slight improvement of activity against G...
متن کاملsome properties of fuzzy hilbert spaces and norm of operators
in this thesis, at first we investigate the bounded inverse theorem on fuzzy normed linear spaces and study the set of all compact operators on these spaces. then we introduce the notions of fuzzy boundedness and investigate a new norm operators and the relationship between continuity and boundedness. and, we show that the space of all fuzzy bounded operators is complete. finally, we define...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1990
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.43.574